MCPH1

Across TCGA patient cohorts, MCPH1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCPH1-associated genes across cancer lineages are ATM, mTOR_pS2448, and ASNS. Each is linked with MCPH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCPH1-to-partner and partner-to-MCPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MCPH1-low versus MCPH1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCPH1→partner) and Y-score (partner→MCPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.412	-2.115	.013	.017	3	3
UCEC	mTOR_pS2448 →	-0.134	-2.565	.014	.010	3	2
UCEC	ASNS →	+0.613	+2.807	<.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.793	+1.926	<.001	.008	3	2
SKCM	Annexin_VII →	-0.183	-3.169	.024	.019	3	1
UCEC	EGFR_pY1068 →	-0.234	-2.736	.011	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ATM by MCPH1 expression — UCEC

Explore this box plot interactively →