MCPH1

Across TCGA cell cohorts, MCPH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,556 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MCPH1-associated GO terms across cancer lineages are Positive regulation of telomere capping, Negative regulation of sister chromatid cohesion, and Regulation of heterochromatin organization. Each is linked with MCPH1 in more than 13 cancer types. Because this analysis shows association rather than direction, both MCPH1-to-partner and partner-to-MCPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of telomere capping grouped by MCPH1-low versus MCPH1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MCPH1→partner) and Y-score (partner→MCPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of telomere capping →	+0.119	+0.908	<.001	<.001	3	14
STOMACH	Negative regulation of sister chromatid cohesion →	+0.179	+1.061	<.001	<.001	3	14
URINARY_TRACT	Regulation of heterochromatin organization →	+0.118	+0.769	<.001	.003	3	14
LIVER	Regulation of regulatory ncRNA-mediated heterochromatin formation →	+0.144	+0.739	<.001	.001	3	14
LIVER	Negative regulation of heterochromatin organization →	+0.166	+0.718	<.001	.008	3	14
URINARY_TRACT	Regulation of heterochromatin formation →	+0.165	+1.100	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,556 associations by consensus.

Positive regulation of telomere capping by MCPH1 expression — STOMACH

Explore this box plot interactively →