MCPH1

Across TCGA cell cohorts, MCPH1 mutation is significantly associated with the RNA expression of many other genes, with 104 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCPH1-associated genes across cancer lineages are SLC32A1, ACOT12, and PRDM7. Each is linked with MCPH1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCPH1-to-partner and partner-to-MCPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC32A1 grouped by MCPH1-low versus MCPH1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCPH1→partner) and Y-score (partner→MCPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC32A1 →	+0.011	+4.714	<.001	.002	3	3
PANCREAS	ACOT12 →	+0.348	+4.039	<.001	.003	3	2
BLOOD_Leukemia	PRDM7 →	+0.457	+2.760	.001	.004	3	2
BLOOD_Leukemia	SLC26A5 →	+0.028	+2.697	.003	.006	3	2
LARGE_INTESTINE	SRSF12 →	+0.323	+3.614	.003	.001	3	2
SKIN	OR2A25 →	+0.030	+2.560	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 104 associations by consensus.

SLC32A1 by MCPH1 expression — BLOOD_Lymphoma

Explore this box plot interactively →