MCPH1-AS1

Across TCGA pan-cancer cohorts, MCPH1-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated MCPH1-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MCPH1-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MCPH1-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and THYM show a favorable association.

KIRC, STAD, and LIHC are the cancer types where MCPH1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.739	0.534	<.001	61	view →
STAD	DFS	Quartile	IV	0.130	0.765	.002	36	view →
LIHC	OS	Tertile	II,III,IV	0.541	0.827	<.001	36	view →
THYM	DFS	Median	All	0.872	0.653	.001	33	view →
CESC	OS	Quartile	IV	0.739	0.247	.021	26	view →
KIRP	DFS	Median	All	0.892	0.571	.006	24	view →
BLCA	OS	Tertile	IV	0.197	0.453	.019	21	view →
HNSC	DFS	Tertile	IV	0.771	0.548	.001	19	view →
LGG	OS	Median	All	0.929	0.843	.005	16	view →
READ	OS	Quartile	II,III,IV	1.000	0.847	.012	10	view →
SKCM	OS	Median	III,IV	0.855	0.734	.017	9	view →
GBM	OS	Median	All	0.555	0.290	.002	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

MCPH1-AS1–KIRC (OS)

Open the KIRC breakdown →