Across TCGA patient cohorts, MCMBP mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCMBP-associated genes across cancer lineages are eIF4E, TFRC, and ERK2. Each is linked with MCMBP in more than 3 cancer types. Because this analysis shows association rather than direction, both MCMBP-to-partner and partner-to-MCMBP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCMBP→partner) and Y-score (partner→MCMBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.180	+3.335	.023	.005	3	4
UCEC	TFRC →	+0.418	+2.999	.035	.035	3	3
UCEC	ERK2 →	+0.194	+2.459	.007	.018	3	2
UCEC	JNK_pT183_Y185 →	-0.152	-1.401	.016	.046	3	2
UCEC	PCNA →	+0.275	+2.807	<.001	.002	3	2
UCEC	ATM →	-0.618	-2.169	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

MCMBP survival (RNA) · tumor vs normal (RNA) · all MCMBP data types