Across TCGA cell cohorts, MCMBP mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCMBP-associated genes across cancer lineages are VSX2, PTCHD1, and KRT85. Each is linked with MCMBP in more than 1 cancer types. Because this analysis shows association rather than direction, both MCMBP-to-partner and partner-to-MCMBP results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCMBP→partner) and Y-score (partner→MCMBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	VSX2 →	+0.029	+3.744	<.001	.003	3	1
BLOOD_Leukemia	PTCHD1 →	+0.537	+3.455	<.001	.002	3	1
LARGE_INTESTINE	KRT85 →	+0.351	+3.823	.001	.006	3	1
LARGE_INTESTINE	CLDN17 →	+0.062	+3.345	<.001	.007	3	1
LARGE_INTESTINE	SCGB3A2 →	+0.256	+3.510	.008	.003	3	1
LARGE_INTESTINE	OR1L6 →	+0.018	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

MCMBP survival (RNA) · tumor vs normal (RNA) · all MCMBP data types