MCM9

Across TCGA patient cohorts, MCM9 mutation is significantly associated with the RNA expression of many other genes, with 2,191 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCM9-associated genes across cancer lineages are MIR7702, CCL4, and UHRF1. Each is linked with MCM9 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCM9-to-partner and partner-to-MCM9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7702 grouped by MCM9-low versus MCM9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM9→partner) and Y-score (partner→MCM9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR7702 →	+0.155	+3.668	<.001	.009	3	2
UCEC	CCL4 →	+0.742	+2.269	.003	.001	3	2
UCEC	UHRF1 →	+0.985	+2.818	<.001	.001	3	2
COAD	PPIAP79 →	+0.341	+2.341	<.001	.008	3	2
COAD	PSMA6P1 →	+1.074	+3.335	<.001	.005	3	2
COAD	GAPDHP72 →	+1.103	+3.209	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,191 associations by consensus.

MIR7702 by MCM9 expression — UCEC

Explore this box plot interactively →