MCM9

Across TCGA patient cohorts, MCM9 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCM9-associated genes across cancer lineages are ASNS, 14-3-3_beta, and EGFR_pY1068. Each is linked with MCM9 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCM9-to-partner and partner-to-MCM9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by MCM9-low versus MCM9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM9→partner) and Y-score (partner→MCM9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.525	+2.321	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.143	-3.673	<.001	.001	3	1
UCEC	EGFR_pY1068 →	-0.312	-3.087	.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.189	-2.700	<.001	.006	3	1
UCEC	ACC_pS79 →	+0.353	+1.906	.011	.016	3	1
UCEC	ACC1 →	+0.523	+3.472	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ASNS by MCM9 expression — UCEC

Explore this box plot interactively →