MCM9

Across TCGA cell cohorts, MCM9 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,989 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MCM9-associated GO terms across cancer lineages are Mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication, Mismatch repair, and DNA-templated DNA replication. Each is linked with MCM9 in more than 19 cancer types. Because this analysis shows association rather than direction, both MCM9-to-partner and partner-to-MCM9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication grouped by MCM9-low versus MCM9-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM9→partner) and Y-score (partner→MCM9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication →	+0.118	+0.910	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Mismatch repair →	+0.127	+1.000	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	DNA-templated DNA replication →	+0.120	+0.850	<.001	.002	3	17
SOFT_TISSUE	Positive regulation of double-strand break repair →	+0.088	+0.999	<.001	<.001	3	16
BONE	Replication fork processing →	+0.100	+0.711	<.001	<.001	3	16
BONE	DNA-templated DNA replication maintenance of fidelity →	+0.101	+0.711	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,989 associations by consensus.

Mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication by MCM9 expression — BREAST

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