MCM9

Across TCGA cell cohorts, MCM9 mutation is significantly associated with the RNA expression of many other genes, with 77 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MCM9-associated genes across cancer lineages are LRIT1, SLC32A1, and KSR2. Each is linked with MCM9 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCM9-to-partner and partner-to-MCM9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRIT1 grouped by MCM9-low versus MCM9-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM9→partner) and Y-score (partner→MCM9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LRIT1 →	+0.016	+5.209	<.001	.005	3	2
BLOOD_Leukemia	SLC32A1 →	+0.430	+3.223	.003	.004	3	2
BLOOD_Leukemia	KSR2 →	+0.377	+3.540	<.001	.005	3	2
BLOOD_Leukemia	FIGLA →	+0.015	+4.247	<.001	.004	3	2
LARGE_INTESTINE	PITX3 →	+0.169	+3.374	<.001	.005	3	1
LARGE_INTESTINE	ECE2 →	+0.208	+2.791	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

LRIT1 by MCM9 expression — BLOOD_Lymphoma

Explore this box plot interactively →