MCM8-AS1

Across TCGA pan-cancer cohorts, MCM8-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated MCM8-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher MCM8-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MCM8-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, LGG, and LUSC are the cancer types where MCM8-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.582	0.375	.001	93	view →
LGG	DFS	Median	All	0.659	0.808	<.001	37	view →
LUSC	DFS	Tertile	III,IV	0.539	0.769	.002	36	view →
SKCM	OS	Tertile	III,IV	0.781	0.599	.004	23	view →
READ	OS	Median	All	0.815	0.486	.003	21	view →
SARC	OS	Quartile	All	0.340	0.714	<.001	18	view →
STAD	OS	Quartile	All	0.673	0.508	.013	11	view →
PRAD	OS	Median	All	0.988	1.000	.021	10	view →
KIRC	DFS	Quartile	All	0.785	0.936	.015	8	view →
UVM	OS	Tertile	III,IV	0.448	0.868	.037	8	view →
KIRP	OS	Median	IV	0.679	0.046	.030	7	view →
CHOL	OS	Median	IV	0.208	0.948	.010	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

MCM8-AS1–HNSC (OS)

Open the HNSC breakdown →