MCM6

Across TCGA pan-cancer cohorts, MCM6 mass-spec protein is linked to patient survival in 9 of 34 cancer types, making it a survival-associated MCM6 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MCM6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MCM6 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

COAD, LUAD, and LSCC are the cancer types where MCM6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.890	1.000	.029	24	view →
LUAD	OS	Tertile	All	0.585	1.000	<.001	17	view →
LSCC	DFS	Tertile	II,III,IV	0.810	0.473	.013	13	view →
PDAC	OS	Quartile	II,III,IV	0.718	1.000	.008	10	view →
HNSC	OS	Tertile	All	0.786	0.923	.013	5	view →
OV	DFS	Quartile	All	0.782	1.000	.039	4	view →
UCEC	DFS	Median	III,IV	0.904	0.445	.037	4	view →
GBM	DFS	Quartile	All	0.293	0.535	.028	3	view →
CCRCC	OS	Tertile	All	0.655	1.000	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

MCM6–COAD (DFS)

Open the COAD breakdown →