MCM6

Across TCGA patient cohorts, MCM6 mutation is significantly associated with the RNA expression of many other genes, with 1,306 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCM6-associated genes across cancer lineages are FTH1P9, MIR6803, and RPL23AP54. Each is linked with MCM6 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCM6-to-partner and partner-to-MCM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTH1P9 grouped by MCM6-low versus MCM6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM6→partner) and Y-score (partner→MCM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FTH1P9 →	+0.046	+5.421	<.001	.001	3	3
UCEC	MIR6803 →	+0.124	+4.156	<.001	.004	3	3
BRCA	RPL23AP54 →	+0.129	+5.760	<.001	.003	3	3
HNSC	MIR6792 →	+0.614	+6.111	<.001	.002	3	3
COAD	RN7SL554P →	+0.431	+3.357	<.001	.006	3	3
UCEC	MPG →	+0.486	+2.246	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,306 associations by consensus.

FTH1P9 by MCM6 expression — SKCM

Explore this box plot interactively →