MCM6

Across TCGA cell cohorts, MCM6 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,198 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MCM6-associated GO terms across cancer lineages are Double-strand break repair via break-induced replication, Regulation of chromosome condensation, and DNA strand elongation involved in DNA replication. Each is linked with MCM6 in more than 19 cancer types. Because this analysis shows association rather than direction, both MCM6-to-partner and partner-to-MCM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Double-strand break repair via break-induced replication grouped by MCM6-low versus MCM6-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM6→partner) and Y-score (partner→MCM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Double-strand break repair via break-induced replication →	+0.243	+1.112	.004	.001	3	20
BLOOD_Myeloma	Regulation of chromosome condensation →	+0.205	+1.093	.007	.004	3	20
BONE	DNA strand elongation involved in DNA replication →	+0.150	+0.786	<.001	<.001	3	20
OESOPHAGUS	Mitotic sister chromatid cohesion →	+0.120	+0.890	.002	.007	3	20
UPPER_AERODIGESTIVE_TRACT	DNA strand elongation →	+0.207	+2.216	<.001	<.001	3	19
SOFT_TISSUE	Chromosome condensation →	+0.158	+1.015	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,198 associations by consensus.

Double-strand break repair via break-induced replication by MCM6 expression — BONE

Explore this box plot interactively →