MCM6

Across TCGA cell cohorts, MCM6 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MCM6-associated genes across cancer lineages are GRK7, RHOXF2, and CFHR5. Each is linked with MCM6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCM6-to-partner and partner-to-MCM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRK7 grouped by MCM6-low versus MCM6-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM6→partner) and Y-score (partner→MCM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GRK7 →	+0.070	+3.700	<.001	.004	3	1
LUNG_NSCLC_LUAD	RHOXF2 →	+0.877	+3.824	<.001	.003	3	1
LUNG_NSCLC_LUAD	CFHR5 →	+0.011	+4.415	<.001	<.001	3	1
LUNG_NSCLC_LUAD	CT47A1 →	+0.023	+4.266	<.001	.004	3	1
BLOOD_Leukemia	ODF4 →	+0.050	+4.922	<.001	.009	3	1
SKIN	CEACAM8 →	+0.011	+5.217	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

GRK7 by MCM6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →