MCM6

Across TCGA cell cohorts, MCM6 mutation is significantly associated with the mutation status of many other genes, with 2,950 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCM6-associated genes across cancer lineages are DES, ADCK1, and CNKSR2. Each is linked with MCM6 in more than 3 cancer types. Because this analysis shows association rather than direction, both MCM6-to-partner and partner-to-MCM6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DES grouped by MCM6-low versus MCM6-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM6→partner) and Y-score (partner→MCM6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DES →	+5.053	+4.239	.007	.007	1	4
BLOOD_Leukemia	ADCK1 →	+3.548	+3.845	.003	.003	1	4
BLOOD_Leukemia	CNKSR2 →	+3.870	+4.050	.002	.002	1	3
SKIN	RIN1 →	+5.053	+4.239	.007	.007	1	3
SKIN	SLC4A5 →	+3.638	+4.117	.002	.002	1	3
SKIN	ARHGEF1 →	+5.638	+4.977	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,950 associations by consensus.

DES by MCM6 expression — SKIN

Explore this box plot interactively →