MCM5

Across TCGA pan-cancer cohorts, MCM5 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MCM5 data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MCM5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MCM5 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

COAD, LUAD, and LSCC are the cancer types where MCM5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.892	1.000	.018	30	view →
LUAD	OS	Median	All	0.584	1.000	<.001	18	view →
LSCC	DFS	Tertile	II,III,IV	0.856	0.542	.020	16	view →
PDAC	OS	Quartile	II,III,IV	0.595	0.938	.002	14	view →
HNSC	OS	Median	All	0.380	1.000	.008	13	view →
GBM	DFS	Quartile	All	0.285	0.548	.014	6	view →
CCRCC	OS	Tertile	All	0.655	1.000	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MCM5–COAD (DFS)

Open the COAD breakdown →