MCM5

Across TCGA patient cohorts, MCM5 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCM5-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and PCNA. Each is linked with MCM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCM5-to-partner and partner-to-MCM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by MCM5-low versus MCM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM5→partner) and Y-score (partner→MCM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.160	-2.321	.011	.033	3	2
UCEC	MEK1 →	+0.466	+2.584	<.001	.010	3	2
UCEC	PCNA →	+0.270	+2.584	<.001	.010	3	2
UCEC	Rad50 →	-0.250	-1.415	.005	.046	3	2
UCEC	STAT3_pY705 →	-0.410	-2.115	<.001	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.478	+2.019	.031	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

JNK_pT183_Y185 by MCM5 expression — UCEC

Explore this box plot interactively →