MCM5

Across TCGA cell cohorts, MCM5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,492 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MCM5-associated GO terms across cancer lineages are Regulation of chromosome condensation, Double-strand break repair via break-induced replication, and Mitotic DNA replication. Each is linked with MCM5 in more than 18 cancer types. Because this analysis shows association rather than direction, both MCM5-to-partner and partner-to-MCM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromosome condensation grouped by MCM5-low versus MCM5-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM5→partner) and Y-score (partner→MCM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of chromosome condensation →	+0.228	+1.537	<.001	.001	3	19
BONE	Double-strand break repair via break-induced replication →	+0.223	+1.356	.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Mitotic DNA replication →	+0.232	+1.585	<.001	<.001	3	19
BONE	Nuclear DNA replication →	+0.170	+1.309	.001	.001	3	19
BONE	Cell cycle DNA replication →	+0.166	+1.254	.001	.001	3	19
OESOPHAGUS	Spindle elongation →	+0.271	+1.523	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,492 associations by consensus.

Regulation of chromosome condensation by MCM5 expression — OESOPHAGUS

Explore this box plot interactively →