MCM5

Across TCGA cell cohorts, MCM5 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCM5-associated genes across cancer lineages are REG1B, LCT, and OPN4. Each is linked with MCM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCM5-to-partner and partner-to-MCM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by MCM5-low versus MCM5-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM5→partner) and Y-score (partner→MCM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	REG1B →	+0.105	+6.000	<.001	<.001	3	2
SKIN	LCT →	+0.067	+4.684	<.001	.002	3	1
SKIN	OPN4 →	+0.027	+4.273	.008	.006	3	1
SKIN	OR5B3 →	+0.033	+4.415	<.001	.007	3	1
SKIN	KRTAP11-1 →	+0.016	+4.415	<.001	.007	3	1
SKIN	BPIFB3 →	+0.022	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

REG1B by MCM5 expression — SKIN

Explore this box plot interactively →