MCM4

Across TCGA pan-cancer cohorts, MCM4 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated MCM4 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher MCM4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MCM4 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LUAD, HNSC, and COAD are the cancer types where MCM4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.588	1.000	.001	17	view →
HNSC	OS	Tertile	All	0.789	0.923	.016	15	view →
COAD	DFS	Tertile	All	0.915	1.000	.032	12	view →
LSCC	DFS	Quartile	II,III,IV	0.886	0.557	.019	11	view →
PDAC	OS	Quartile	II,III,IV	0.735	0.932	.030	10	view →
GBM	OS	Quartile	All	0.810	1.000	.009	6	view →
UCEC	DFS	Median	III,IV	0.904	0.445	.037	4	view →
CCRCC	OS	Tertile	All	0.655	1.000	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

MCM4–LUAD (OS)

Open the LUAD breakdown →