MCM2

Across TCGA patient cohorts, MCM2 mutation is significantly associated with the RNA expression of many other genes, with 2,134 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCM2-associated genes across cancer lineages are PPCDC, RASSF1, and CINP. Each is linked with MCM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCM2-to-partner and partner-to-MCM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPCDC grouped by MCM2-low versus MCM2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM2→partner) and Y-score (partner→MCM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PPCDC →	+0.343	+2.508	.001	.001	3	3
SKCM	RASSF1 →	+0.554	+2.031	<.001	.005	3	3
UCEC	CINP →	+0.238	+3.119	.001	<.001	3	3
UCEC	KCTD9 →	+0.603	+1.765	<.001	<.001	3	3
UCEC	MRPL39 →	+0.392	+2.010	<.001	<.001	3	3
UCEC	LSM3 →	+0.372	+1.530	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,134 associations by consensus.

PPCDC by MCM2 expression — SKCM

Explore this box plot interactively →