MCM2

Across TCGA patient cohorts, MCM2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCM2-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and ERK2. Each is linked with MCM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCM2-to-partner and partner-to-MCM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MCM2-low versus MCM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM2→partner) and Y-score (partner→MCM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.495	+1.604	.011	.021	3	3
UCEC	eIF4E →	+0.149	+1.652	.032	.006	3	2
UCEC	ERK2 →	+0.147	+2.459	.020	.018	3	2
SKCM	HSP70 →	-0.535	-3.700	.028	.001	3	2
UCEC	Ku80 →	+0.268	+1.951	<.001	<.001	3	2
SKCM	HER2_pY1248 →	-0.140	-2.584	.038	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by MCM2 expression — UCEC

Explore this box plot interactively →