MCM2

Across TCGA cell cohorts, MCM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,961 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MCM2-associated GO terms across cancer lineages are Double-strand break repair via break-induced replication, DNA-templated DNA replication, and DNA strand elongation involved in DNA replication. Each is linked with MCM2 in more than 19 cancer types. Because this analysis shows association rather than direction, both MCM2-to-partner and partner-to-MCM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Double-strand break repair via break-induced replication grouped by MCM2-low versus MCM2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM2→partner) and Y-score (partner→MCM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Double-strand break repair via break-induced replication →	+0.253	+1.455	<.001	.001	3	20
OESOPHAGUS	DNA-templated DNA replication →	+0.130	+1.250	<.001	<.001	3	20
SOFT_TISSUE	DNA strand elongation involved in DNA replication →	+0.190	+1.202	<.001	<.001	3	20
OESOPHAGUS	Mitotic DNA replication →	+0.171	+1.204	.003	.001	3	20
BONE	Mitotic DNA replication checkpoint signaling →	+0.246	+1.944	<.001	<.001	3	20
OESOPHAGUS	DNA-templated DNA replication maintenance of fidelity →	+0.149	+1.385	<.001	.002	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,961 associations by consensus.

Double-strand break repair via break-induced replication by MCM2 expression — OESOPHAGUS

Explore this box plot interactively →