MCM2

Across TCGA cell cohorts, MCM2 mutation is significantly associated with the RNA expression of many other genes, with 92 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCM2-associated genes across cancer lineages are SLURP2, HSCB, and GSS. Each is linked with MCM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCM2-to-partner and partner-to-MCM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLURP2 grouped by MCM2-low versus MCM2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM2→partner) and Y-score (partner→MCM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLURP2 →	+0.451	+5.029	<.001	.006	3	1
LARGE_INTESTINE	HSCB →	+0.475	+3.169	.003	.006	3	1
LARGE_INTESTINE	GSS →	-0.450	-3.321	.006	.003	3	1
LARGE_INTESTINE	BMF →	-0.766	-2.371	.009	<.001	3	1
LARGE_INTESTINE	BAG2 →	+0.779	+1.949	.005	.002	3	1
LARGE_INTESTINE	BCAS2 →	+0.507	+2.458	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

SLURP2 by MCM2 expression — LUNG_SCLC

Explore this box plot interactively →