MCM10

Across TCGA cell cohorts, MCM10 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,268 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MCM10-associated GO terms across cancer lineages are Sister chromatid segregation, DNA-templated DNA replication, and DNA replication initiation. Each is linked with MCM10 in more than 19 cancer types. Because this analysis shows association rather than direction, both MCM10-to-partner and partner-to-MCM10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sister chromatid segregation grouped by MCM10-low versus MCM10-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM10→partner) and Y-score (partner→MCM10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Sister chromatid segregation →	+0.172	+1.819	<.001	<.001	3	20
BONE	DNA-templated DNA replication →	+0.165	+1.752	<.001	.001	3	20
BONE	DNA replication initiation →	+0.253	+2.072	<.001	<.001	3	20
KIDNEY	Pericentric heterochromatin formation →	+0.167	+1.333	<.001	<.001	3	20
BONE	Meiotic cell cycle →	+0.106	+1.791	.004	.001	3	20
OESOPHAGUS	DNA strand elongation →	+0.216	+1.732	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,268 associations by consensus.

Sister chromatid segregation by MCM10 expression — BONE

Explore this box plot interactively →