MCL1

Across TCGA pan-cancer cohorts, MCL1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MCL1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher MCL1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MCL1 expression acts as an unfavorable survival marker.

GBM, COAD, and CCRCC are the cancer types where MCL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.606	0.884	<.001	14	view →
COAD	DFS	Median	All	0.903	1.000	.032	12	view →
CCRCC	DFS	Tertile	II,III,IV	0.503	0.858	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MCL1–GBM (DFS)

Open the GBM breakdown →