MCIDAS

Across TCGA patient cohorts, MCIDAS mutation is significantly associated with the RNA expression of many other genes, with 288 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCIDAS-associated genes across cancer lineages are ATPSCKMT, NDUFC2, and GUF1. Each is linked with MCIDAS in more than 1 cancer types. Because this analysis shows association rather than direction, both MCIDAS-to-partner and partner-to-MCIDAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATPSCKMT grouped by MCIDAS-low versus MCIDAS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCIDAS→partner) and Y-score (partner→MCIDAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATPSCKMT →	+0.489	+3.354	.008	.005	3	1
UCEC	NDUFC2 →	+0.660	+3.212	.002	.009	3	1
UCEC	GUF1 →	+0.660	+3.595	<.001	.001	3	1
UCEC	RAD17 →	+0.575	+3.379	.002	.004	3	1
UCEC	SREK1IP1 →	+0.490	+3.584	.006	.003	3	1
UCEC	VPS37A →	+0.663	+3.595	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 288 associations by consensus.

ATPSCKMT by MCIDAS expression — UCEC

Explore this box plot interactively →