MCIDAS

Across TCGA patient cohorts, MCIDAS mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCIDAS-associated genes across cancer lineages are Endothelial cells, Keratinocytes, and lymphatic Endothelial cells. Each is linked with MCIDAS in more than 1 cancer types. Because this analysis shows association rather than direction, both MCIDAS-to-partner and partner-to-MCIDAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endothelial cells grouped by MCIDAS-low versus MCIDAS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCIDAS→partner) and Y-score (partner→MCIDAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Endothelial cells →	-0.040	-2.416	.030	.021	3	1
UCEC	Keratinocytes →	-0.014	-2.951	.037	.036	3	1
UCEC	lymphatic Endothelial cells →	-0.024	-3.281	.033	.010	3	1
UCEC	mv Endothelial cells →	-0.029	-3.321	.011	.010	3	1
UCEC	Myocytes →	+0.038	+2.502	.014	.010	3	1
UCEC	Basophils →	+0.170	+3.584	.038	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Endothelial cells by MCIDAS expression — UCEC

Explore this box plot interactively →