MCIDAS

Across TCGA cell cohorts, MCIDAS mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCIDAS-associated genes across cancer lineages are KLHL14, TEX46, and ASB17. Each is linked with MCIDAS in more than 1 cancer types. Because this analysis shows association rather than direction, both MCIDAS-to-partner and partner-to-MCIDAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL14 grouped by MCIDAS-low versus MCIDAS-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCIDAS→partner) and Y-score (partner→MCIDAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KLHL14 →	+0.210	+3.817	<.001	.002	3	1
LARGE_INTESTINE	TEX46 →	+0.196	+3.497	<.001	.004	3	1
STOMACH	ASB17 →	+0.035	+4.432	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

KLHL14 by MCIDAS expression — LARGE_INTESTINE

Explore this box plot interactively →