MCHR2

Across TCGA patient cohorts, MCHR2 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCHR2-associated genes across cancer lineages are ASNS, GAPDH, and Bad_pS112. Each is linked with MCHR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCHR2-to-partner and partner-to-MCHR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by MCHR2-low versus MCHR2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCHR2→partner) and Y-score (partner→MCHR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	ASNS →	+0.740	+2.816	.002	.036	3	2
UCEC	GAPDH →	+0.590	+2.459	.023	.020	2	3
UCEC	Bad_pS112 →	-0.198	-2.459	.028	.020	3	2
SKCM	Di-Ras3 →	+0.103	+2.000	.017	.027	3	1
UCEC	JNK2 →	+0.297	+2.459	.001	.020	3	1
UCEC	MAPK_pT202_Y204 →	-0.663	-2.459	.003	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ASNS by MCHR2 expression — LUSC

Explore this box plot interactively →