MCHR2

Across TCGA cell cohorts, MCHR2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCHR2-associated genes across cancer lineages are COX4I2, SYT10, and SSMEM1. Each is linked with MCHR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCHR2-to-partner and partner-to-MCHR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COX4I2 grouped by MCHR2-low versus MCHR2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCHR2→partner) and Y-score (partner→MCHR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	COX4I2 →	+0.098	+5.228	<.001	.005	3	1
LARGE_INTESTINE	SYT10 →	+0.234	+3.196	<.001	.007	3	1
LARGE_INTESTINE	SSMEM1 →	+0.021	+4.029	.007	.002	3	1
LARGE_INTESTINE	PPDPFL →	+0.045	+3.632	<.001	.003	3	1
LARGE_INTESTINE	PROP1 →	+0.028	+4.376	<.001	<.001	3	1
LARGE_INTESTINE	OR5AK2 →	+0.040	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

COX4I2 by MCHR2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →