MCHR1

Across TCGA patient cohorts, MCHR1 mutation is significantly associated with the RNA expression of many other genes, with 1,724 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCHR1-associated genes across cancer lineages are KCTD9, SLC25A28, and MIER3. Each is linked with MCHR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCHR1-to-partner and partner-to-MCHR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCTD9 grouped by MCHR1-low versus MCHR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCHR1→partner) and Y-score (partner→MCHR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KCTD9 →	+0.513	+1.776	.006	.008	3	3
UCEC	SLC25A28 →	+0.342	+3.617	.001	.001	3	2
UCEC	MIER3 →	+0.472	+2.180	.007	.002	3	2
UCEC	LRR1 →	+0.632	+3.724	<.001	<.001	3	2
UCEC	DUS2 →	+0.366	+3.700	.003	.001	3	2
UCEC	FUT10 →	+0.444	+2.169	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,724 associations by consensus.

KCTD9 by MCHR1 expression — UCEC

Explore this box plot interactively →