MCHR1

Across TCGA patient cohorts, MCHR1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCHR1-associated genes across cancer lineages are Heregulin, MEK1, and MSH2. Each is linked with MCHR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCHR1-to-partner and partner-to-MCHR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by MCHR1-low versus MCHR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCHR1→partner) and Y-score (partner→MCHR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.161	-1.807	.001	.027	3	1
UCEC	MEK1 →	+0.369	+2.321	.014	.006	3	1
UCEC	MSH2 →	-0.265	-3.160	.005	.019	2	2
UCEC	Akt_pT308 →	+0.647	+1.874	.012	.049	3	1
UCEC	Shc_pY317 →	-0.136	-2.000	.030	.030	3	1
UCEC	STAT3_pY705 →	-0.268	-2.311	.013	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Heregulin by MCHR1 expression — UCEC

Explore this box plot interactively →