MCHR1

Across TCGA cell cohorts, MCHR1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MCHR1-associated genes across cancer lineages are OR10R2, GJA8, and SHCBP1L. Each is linked with MCHR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCHR1-to-partner and partner-to-MCHR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10R2 grouped by MCHR1-low versus MCHR1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCHR1→partner) and Y-score (partner→MCHR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR10R2 →	+1.907	+4.551	<.001	.004	3	2
URINARY_TRACT	GJA8 →	+0.020	+5.087	<.001	.004	3	1
URINARY_TRACT	SHCBP1L →	+0.056	+5.087	<.001	.004	3	1
URINARY_TRACT	MROH5 →	+0.006	+5.087	<.001	.004	3	1
BLOOD_Leukemia	TACR3 →	+0.038	+5.060	<.001	.001	3	1
BLOOD_Leukemia	OR10T2 →	+0.743	+4.276	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

OR10R2 by MCHR1 expression — BLOOD_Leukemia

Explore this box plot interactively →