MCHR1

Across TCGA cell cohorts, MCHR1 mutation is significantly associated with the mutation status of many other genes, with 3,210 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MCHR1-associated genes across cancer lineages are RASAL3, SLC38A4, and SPAG17. Each is linked with MCHR1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MCHR1-to-partner and partner-to-MCHR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RASAL3 grouped by MCHR1-low versus MCHR1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCHR1→partner) and Y-score (partner→MCHR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RASAL3 →	+3.655	+4.906	.001	.001	1	4
LARGE_INTESTINE	SLC38A4 →	+3.744	+5.000	<.001	<.001	1	4
SKIN	SPAG17 →	+2.807	+4.247	.007	.007	1	4
BLOOD_Leukemia	ATG9A →	+4.870	+4.560	<.001	<.001	1	4
BLOOD_Leukemia	SEZ6L →	+2.870	+3.347	.009	.009	1	3
BLOOD_Leukemia	ATP13A1 →	+3.799	+5.531	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,210 associations by consensus.

RASAL3 by MCHR1 expression — SKIN

Explore this box plot interactively →