MCFD2

Across TCGA patient cohorts, MCFD2 mutation is significantly associated with the RNA expression of many other genes, with 1,239 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCFD2-associated genes across cancer lineages are RNU6-668P, MRPS21P8, and BTBD10. Each is linked with MCFD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCFD2-to-partner and partner-to-MCFD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-668P grouped by MCFD2-low versus MCFD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCFD2→partner) and Y-score (partner→MCFD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-668P →	+0.270	+3.071	<.001	.001	3	2
UCEC	MRPS21P8 →	+0.172	+2.414	.001	.005	3	2
UCEC	BTBD10 →	+0.472	+3.716	.006	<.001	3	1
UCEC	LIN7C →	+0.634	+3.815	.001	<.001	3	1
UCEC	NPAT →	+0.588	+3.593	.001	.001	3	1
UCEC	CHEK1 →	+0.760	+3.343	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,239 associations by consensus.

RNU6-668P by MCFD2 expression — UCEC

Explore this box plot interactively →