MCF2L2

Across TCGA patient cohorts, MCF2L2 mutation is significantly associated with the RNA expression of many other genes, with 5,601 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCF2L2-associated genes across cancer lineages are PUSL1, AKR1A1, and WRAP53. Each is linked with MCF2L2 in more than 4 cancer types. Because this analysis shows association rather than direction, both MCF2L2-to-partner and partner-to-MCF2L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PUSL1 grouped by MCF2L2-low versus MCF2L2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCF2L2→partner) and Y-score (partner→MCF2L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PUSL1 →	+0.481	+3.459	.003	.005	3	5
COAD	AKR1A1 →	+0.382	+2.262	.003	.005	3	4
COAD	WRAP53 →	+0.594	+2.974	<.001	<.001	3	4
COAD	SDHA →	+0.460	+4.000	<.001	<.001	3	4
UCEC	CHAF1A →	+0.658	+2.176	<.001	<.001	3	4
SKCM	RANBP1 →	+0.441	+3.487	.002	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,601 associations by consensus.

PUSL1 by MCF2L2 expression — COAD

Explore this box plot interactively →