MCF2L

Across TCGA patient cohorts, MCF2L mutation is significantly associated with the RNA expression of many other genes, with 4,912 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCF2L-associated genes across cancer lineages are WDR76, PHF5A, and KDSR. Each is linked with MCF2L in more than 4 cancer types. Because this analysis shows association rather than direction, both MCF2L-to-partner and partner-to-MCF2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR76 grouped by MCF2L-low versus MCF2L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCF2L→partner) and Y-score (partner→MCF2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	WDR76 →	+0.701	+2.150	<.001	<.001	3	5
UCEC	PHF5A →	+0.466	+2.362	<.001	<.001	3	5
COAD	KDSR →	+0.561	+3.615	<.001	.001	3	5
UCEC	C12orf65 →	+0.316	+1.917	<.001	<.001	3	5
COAD	SKA1 →	+0.882	+2.834	<.001	.001	3	4
UCEC	SFXN1 →	+0.508	+3.136	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,912 associations by consensus.

WDR76 by MCF2L expression — UCEC

Explore this box plot interactively →