MCF2L

Across TCGA patient cohorts, MCF2L mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCF2L-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and c-Kit. Each is linked with MCF2L in more than 4 cancer types. Because this analysis shows association rather than direction, both MCF2L-to-partner and partner-to-MCF2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MCF2L-low versus MCF2L-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCF2L→partner) and Y-score (partner→MCF2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.082	+2.601	<.001	.005	3	5
STAD	4E-BP1 →	+0.309	+3.000	.036	.034	3	4
STAD	c-Kit →	-0.334	-3.169	.032	.019	3	3
COAD	PCNA →	+0.231	+1.749	.014	.049	3	3
UCEC	ATM →	-0.543	-2.489	<.001	.001	3	3
COAD	Src →	-0.167	-2.213	.025	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Caspase-7-cleavedD198 by MCF2L expression — COAD

Explore this box plot interactively →