MCF2L

Across TCGA cell cohorts, MCF2L mutation is significantly associated with the RNA expression of many other genes, with 2,114 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCF2L-associated genes across cancer lineages are DEFA6, EIF3L, and SYNGR2. Each is linked with MCF2L in more than 1 cancer types. Because this analysis shows association rather than direction, both MCF2L-to-partner and partner-to-MCF2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA6 grouped by MCF2L-low versus MCF2L-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCF2L→partner) and Y-score (partner→MCF2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DEFA6 →	+0.157	+5.228	<.001	.005	3	2
LARGE_INTESTINE	EIF3L →	+0.545	+3.546	<.001	<.001	3	2
LARGE_INTESTINE	SYNGR2 →	-0.535	-3.520	.005	<.001	3	2
LARGE_INTESTINE	CDKN1B →	+0.732	+3.043	<.001	<.001	3	2
LARGE_INTESTINE	SAT2 →	+0.893	+2.364	<.001	<.001	3	2
LARGE_INTESTINE	RPS3A →	+0.533	+3.237	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,114 associations by consensus.

DEFA6 by MCF2L expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →