MCF2

Across TCGA patient cohorts, MCF2 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCF2-associated genes across cancer lineages are PDCD4, ASNS, and mTOR_pS2448. Each is linked with MCF2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MCF2-to-partner and partner-to-MCF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by MCF2-low versus MCF2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCF2→partner) and Y-score (partner→MCF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PDCD4 →	-0.515	-2.106	.001	.018	3	4
COAD	ASNS →	+0.635	+2.815	<.001	.001	3	3
SKCM	mTOR_pS2448 →	-0.154	-1.362	.015	.035	3	3
UCEC	14-3-3_beta →	-0.071	-1.558	.004	.007	3	3
UCEC	JNK_pT183_Y185 →	-0.113	-1.754	.007	<.001	3	3
UCEC	VHL →	-0.606	-1.000	<.001	.012	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

PDCD4 by MCF2 expression — COAD

Explore this box plot interactively →