MCF2

Across TCGA cell cohorts, MCF2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,023 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MCF2-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Positive regulation of telomerase RNA localization to Cajal body, and Regulation of cytoplasmic translation. Each is linked with MCF2 in more than 6 cancer types. Because this analysis shows association rather than direction, both MCF2-to-partner and partner-to-MCF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by MCF2-low versus MCF2-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MCF2→partner) and Y-score (partner→MCF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Negative regulation of gene expression, epigenetic →	+0.042	+0.376	<.001	<.001	3	7
BLOOD_Leukemia	Positive regulation of telomerase RNA localization to Cajal body →	+0.047	+0.225	<.001	.004	3	7
BONE	Regulation of cytoplasmic translation →	+0.139	+1.156	<.001	.006	3	6
BONE	Spliceosomal snRNP assembly →	+0.100	+0.600	.001	.005	3	6
BONE	Branching morphogenesis of an epithelial tube →	-0.104	-0.666	<.001	<.001	3	6
SKIN	Morphogenesis of an epithelium →	-0.032	-0.633	<.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,023 associations by consensus.

Negative regulation of gene expression, epigenetic by MCF2 expression — BLOOD_Leukemia

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