MCF2

Across TCGA cell cohorts, MCF2 mutation is significantly associated with the RNA expression of many other genes, with 573 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCF2-associated genes across cancer lineages are FER1L5, IFNL2, and ZBTB45. Each is linked with MCF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCF2-to-partner and partner-to-MCF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FER1L5 grouped by MCF2-low versus MCF2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCF2→partner) and Y-score (partner→MCF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FER1L5 →	+0.043	+3.478	.009	.002	3	2
BLOOD_Lymphoma	IFNL2 →	+0.434	+3.584	<.001	.004	3	2
LARGE_INTESTINE	ZBTB45 →	+0.900	+3.212	<.001	.006	3	2
LARGE_INTESTINE	TDRD5 →	+0.897	+3.212	<.001	.006	3	2
LARGE_INTESTINE	SPATA5L1 →	+0.490	+3.212	.002	.006	3	2
LUNG_NSCLC_LUAD	TRAPPC2 →	+0.479	+3.206	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 573 associations by consensus.

FER1L5 by MCF2 expression — SKIN

Explore this box plot interactively →