MCEE

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, MCEE protein abundance is significantly associated with the protein abundance of many other proteins, with 25,202 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible MCEE-associated proteins across cancer lineages are SUCLG2, ACAD8, and ACAT1. Each is linked with MCEE in more than 9 cancer types. Because this analysis shows association rather than direction, both MCEE-to-partner and partner-to-MCEE results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MCEE versus SUCLG2 in CCRCC, with a Pearson correlation of 0.75.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MCEE→partner) and Y-score (partner→MCEE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCSUCLG2 →+0.475+0.483<.001<.001310
BRCAACAD8 →+0.452+0.411<.001<.00139
HNSCACAT1 →+0.575+0.589<.001<.00139
GBMIDH3G →+0.413+0.350<.001<.00139
HNSCACO2 →+0.542+0.587<.001<.00139
UCECBCKDHB →+0.497+0.458<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 25,202 associations by consensus.

MCEE vs SUCLG2 — CCRCC

Per-sample scatter of MCEE vs SUCLG2 in CCRCC (Pearson r = 0.75).

Explore this scatter interactively →

Exploration