MCEE

Across TCGA patient cohorts, MCEE mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCEE-associated genes across cancer lineages are OR2M4, RNU6-1307P, and RNU2-16P. Each is linked with MCEE in more than 1 cancer types. Because this analysis shows association rather than direction, both MCEE-to-partner and partner-to-MCEE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M4 grouped by MCEE-low versus MCEE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCEE→partner) and Y-score (partner→MCEE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	OR2M4 →	+0.176	+5.146	.002	.001	3	1
BLCA	RNU6-1307P →	+0.297	+7.640	<.001	.009	3	1
BLCA	RNU2-16P →	+0.258	+7.640	<.001	.009	3	1
BLCA	RNA5SP24 →	+0.348	+7.640	<.001	.009	3	1
BLCA	RNA5SP480 →	+0.312	+7.640	<.001	.009	3	1
UCEC	SLC22A25 →	+0.083	+4.302	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

OR2M4 by MCEE expression — UCEC

Explore this box plot interactively →