MCEE

Across TCGA cell cohorts, MCEE RNA expression is significantly associated with the go_rna of many other GO terms, with 3,192 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MCEE-associated GO terms across cancer lineages are Succinyl-CoA biosynthetic process, Fatty acid catabolic process, and Regulation of translation initiation in response to endoplasmic reticulum stress. Each is linked with MCEE in more than 16 cancer types. Because this analysis shows association rather than direction, both MCEE-to-partner and partner-to-MCEE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Succinyl-CoA biosynthetic process grouped by MCEE-low versus MCEE-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MCEE→partner) and Y-score (partner→MCEE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Succinyl-CoA biosynthetic process →	+0.137	+1.149	.001	.002	3	17
UPPER_AERODIGESTIVE_TRACT	Fatty acid catabolic process →	+0.080	+0.862	.001	<.001	3	11
OESOPHAGUS	Regulation of translation initiation in response to endoplasmic reticulum stress →	+0.126	+0.782	.003	.009	2	12
UPPER_AERODIGESTIVE_TRACT	Monocarboxylic acid catabolic process →	+0.071	+0.956	.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Glycerophospholipid metabolic process →	+0.036	+0.746	<.001	.001	3	10
BLOOD_Myeloma	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	-0.151	-0.791	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,192 associations by consensus.

Succinyl-CoA biosynthetic process by MCEE expression — OESOPHAGUS

Explore this box plot interactively →