MCCC2

Across TCGA pan-cancer cohorts, MCCC2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MCCC2 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher MCCC2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MCCC2 expression acts as an unfavorable survival marker, although some lineages such as OV and COAD show a favorable association.

OV, COAD, and CCRCC are the cancer types where MCCC2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Median	All	0.894	0.583	.021	12	view →
COAD	DFS	Median	All	1.000	0.920	.015	6	view →
CCRCC	OS	Tertile	All	1.000	0.655	.025	6	view →
PDAC	OS	Tertile	IV	0.491	0.836	.024	6	view →
LUAD	DFS	Median	All	0.471	0.701	.035	2	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.901	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MCCC2–OV (DFS)

Open the OV breakdown →