MCCC2

Across TCGA patient cohorts, MCCC2 mutation is significantly associated with the RNA expression of many other genes, with 3,262 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCCC2-associated genes across cancer lineages are RNU6-1226P, RNU6-517P, and TUBAP15. Each is linked with MCCC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCCC2-to-partner and partner-to-MCCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1226P grouped by MCCC2-low versus MCCC2-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCCC2→partner) and Y-score (partner→MCCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-1226P →	+0.274	+4.497	<.001	.009	3	3
HNSC	RNU6-517P →	+0.315	+5.124	<.001	.008	3	2
LUAD	TUBAP15 →	+0.110	+4.306	.006	<.001	3	2
LUAD	LINC01386 →	+0.183	+4.030	<.001	<.001	3	2
SKCM	SNRPCP15 →	+0.194	+4.199	<.001	.009	3	2
STAD	CDY6P →	+0.051	+5.597	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,262 associations by consensus.

RNU6-1226P by MCCC2 expression — BLCA

Explore this box plot interactively →