MCCC2

Across TCGA patient cohorts, MCCC2 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCCC2-associated genes across cancer lineages are eEF2, Notch1, and Paxillin. Each is linked with MCCC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCCC2-to-partner and partner-to-MCCC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by MCCC2-low versus MCCC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCCC2→partner) and Y-score (partner→MCCC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.456	+3.169	.002	.018	3	2
UCEC	Notch1 →	+0.228	+2.335	<.001	.018	3	2
UCEC	Paxillin →	+0.247	+3.331	.024	.005	3	2
UCEC	EGFR_pY1068 →	-0.275	-2.906	.009	.001	3	1
UCEC	A-Raf_pS299 →	-0.164	-3.584	.001	.002	3	1
UCEC	Gab2 →	+0.396	+2.321	.008	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

eEF2 by MCCC2 expression — UCEC

Explore this box plot interactively →